Non-coding RNAs and Cancer by Muller Fabbri MD, Ph.D. (auth.), Muller Fabbri (eds.)

By Muller Fabbri MD, Ph.D. (auth.), Muller Fabbri (eds.)

The discovery of microRNAs and its function as gene expression regulators in human carcinogenesis represents some of the most very important clinical achievements of the decade. extra lately, different non-coding RNAs were chanced on and its implications in melanoma are rising besides, suggesting a broader than expected involvement of the non-coding genome in melanoma. in addition, thoroughly new and unforeseen services for microRNAs are being published, resulting in the identity of latest anticancer molecular objectives. This ebook represents a accomplished advisor on non-coding RNAs and melanoma, spanning from its function as melanoma biomarkers, to delivering the main precious bioinformatic instruments, to featuring the most appropriate discoveries, which shows how those interesting molecules act as high-quality orchestrators of melanoma biology.

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This allows the polymerase to cleave away the fluorescent label as part of the incorporation process leaving behind a natural strand of DNA. The second innovation consists on an optical waveguide called “the zero-mode waveguide,” which enables the observation of individual molecules against a background of labeled nucleotides while maintaining a high signal to noise ratio [46]. This technology is therefore, single molecule and real-time. 5 Computational Methods for Analysis After sequencing of the RNA transcriptome, the next critical challenge is to manage the terabytes of data produced which requires powerful computing and storage resources along with efficient algorithms.

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MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell. 2007;131(1):146–59. 122. Hebert SS et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer’s disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A. 2008;105(17):6415–20. 123. Kim J et al. A MicroRNA feedback circuit in midbrain dopamine neurons. Science. 2007;317(5842):1220–4. 124. Care A et al. MicroRNA-133 controls cardiac hypertrophy. Nat Med. 2007;13(5):613–8.

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