Apoptosis, Senescence, and Cancer by Scott H. Kaufmann MD, PhD (auth.), David A. Gewirtz, Shawn

By Scott H. Kaufmann MD, PhD (auth.), David A. Gewirtz, Shawn E. Holt, Steven Grant (eds.)

Apoptosis, Senescence and melanoma offers perception into validated practices and examine into apoptosis and senescence via completely interpreting novel and rising concepts and learn within the fields of cellphone dying pathways, senescence development arrest, medicines and resistance, DNA harm reaction, and different subject matters which nonetheless carry mysteries for researchers.

The quantity is split into six effortless to persist with sections. the 1st is Apoptosis and replacement Modes of cellphone loss of life, via chapters on Telomeres and Telomerase, Senescence, Genomic Instability and Tumorigenesis. The 3rd half covers DNA harm reaction, Signaling Pathways and Tumorigenesis, whereas the fourth delves into Resistance and Sensitization. The publication concludes with validated melanoma cures and a piece which seems towards the longer term with contemporary and constructing melanoma Therapies.

In overall, this quantity presents simple scientists and clinicians with a deeper and extra entire realizing of the mobile responses of malignancies that could confirm the effectiveness of remedy, either within the preliminary phases of the affliction in addition to in affliction recurrence.

Show description

Read Online or Download Apoptosis, Senescence, and Cancer PDF

Best cancer books

Head and Neck Cancer Imaging (Medical Radiology / Diagnostic Imaging)

Imaging is essential within the multidisciplinary method of head and neck melanoma administration. The swift technological improvement of contemporary years makes it priceless for all contributors of the multidisciplinary group to appreciate the aptitude functions, obstacles, and benefits of present and evolving imaging applied sciences.

Cancer Chemotherapy in Clinical Practice

The decade has visible many dramatic adjustments in melanoma chemotherapy, with the creation of a few new types of therapy in addition to vital advancements within the extra conventional fields of cytotoxic and hormonal treatment. This publication summarises the complete variety of systemic melanoma treatments, explaining their mode of motion and strength side-effects, in addition to their scientific purposes.

Stem Cells and Cancer Stem Cells, Volume 11: Therapeutic Applications in Disease and injury

Quantity eleven during this sequence discusses healing purposes of stem cells in illness and tissue harm. insurance comprises pluripotent stem cells, that may supply upward thrust to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, that could generate all cells in a selected lineage and unipotent stem cells, which may supply upward thrust to simply one mobile kind.

The Molecular Basis of Human Cancer

Molecular biology holds nice promise for the improvement of recent ideas for melanoma prevention and remedy. within the Molecular foundation of Human melanoma, across the world popular uncomplicated and scientific scientists supply an account of our greatest present figuring out of the genetics of melanoma. those authoritative participants describe intimately all of the recognized molecular mechanisms governing neoplastic transformation within the breast, prostate, lung, liver, colon, epidermis, and within the leukemias and lymphomas.

Extra info for Apoptosis, Senescence, and Cancer

Sample text

Phase I clinical and laboratory evaluation of topotecan and cytarabine in patients with acute leukemia. J Clin Oncol 1997; 15(1):44–51. 8. Stahnke K, Fulda S, Friesen C, Staub G, Debatin K-M. Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy. Blood 2001; 98:3066–73. 9. Byrd JC, Kitada S, Flinn IW, et al. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction.

Yin DX, Schimke RT. Bcl-2 Expression delays drug-induced apoptosis but does not increase clonogenic survival after drug treatment in HeLa cells. Cancer Res 1995; 55:4922–8. 271. Simonian PL, Grillot DA, Nunez G. Bcl-2 and Bcl-XL can differentially block chemotherapyinduced cell death. Blood 1997;90:1208–16. 272. Liu R, Page C, Beidler DR, Wicha MS, Nunez G. Overexpression of Bcl-xL promotes chemotherapy resistance of mammary tumors in a syngeneic mouse model. Am J Pathol 1999; 155:1861–7. 273. McCurrach ME, Conner TM, Knudson CM, Korsmeyer SJ, Lower SW.

151. Uren AG, Wong L, Pakusch M, et al. Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. Curr Biol 2000; 10(21):1319–28. 152. Li F. Survivin study: what is the next wave. J Cell Physiol 2003; 197(1):8–29. 153. Yang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 2000; 288:874–7. 154. Huang H-K, Joazeiro CAP, Bonfoco E, Kamada S, Leverson JD, Hunter T.

Download PDF sample

Rated 4.51 of 5 – based on 6 votes