By Sarah Shafer Berger PH.D., Marian Tanofsky-Kraff PH.D. (auth.), Nicole M. Avena (eds.)
The progress of the sector of consuming ailment examine has ended in an unlimited array of empirical articles, and the improvement of latest animal types that may be used to review those issues keeps to stimulate new learn. Animal types of consuming Disorders serves as a set of special options contributed through specialists within the box who're well-versed within the improvement and implementation of those types. considering that consuming issues are advanced and certain as a result of a mix of environmental, genetic, and social factors, the specified chapters of this quantity were designed to spotlight assorted contributing elements. jointly, those chapters provide a finished and consultant evaluation of either lately built and vintage methodologies utilized in the learn of consuming issues. Written for the preferred Neuromethods sequence, this paintings includes the type of thorough description and implementation recommendation that provides profitable results.
Authoritative and functional, Animal types of consuming Disorders goals to help researchers within the use of animal versions to help of their research and characterization of the behaviors and neurochemical adjustments linked to those devastating disorders.
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Extra resources for Animal Models of Eating Disorders
Second, the stressful experience implies a relationship with HPF that resembles the approach-avoidance stress over “forbidden” food that is very common among human binge eaters, thus providing a further element of face validity. 2. The HPF Rather that using sweet biscuits, which usually generate a large amount of spillage, a HPF formulated as a paste was employed. 33 kcal/g; 56%, 31%, and 7% from carbohydrate, fat, and protein, respectively), (b) grounded food pellets 4RF18 (Mucedola, Settimo Milanese, Italy), and (c) water in the following percent ratio: 52% Nutella, 33% food pellets, 15% water.
Following examination of vaginal smears on the test day, immediately after the HPF intake test, statistical analysis revealed that HPF intake was significantly lower during the estrus phase both in NR + NS and R + S rats (82). HPF intake of R + S rats was significantly higher than that of NR + NS rats during proestrus, metaestrus, and diestrus; however, during estrus it was only slightly higher in R + S rats, and the difference between the two groups was not statistically significant (Fig. 5). These findings indicate that BE in our model does not occur during the estrus phase and that the observed variability in the BE response can be almost completely abolished if female rats in estrus are not included in the statistical evaluation.
The corticotrophin-releasing factor (CRF)-1 receptor antagonist R121919 selectively inhibited BE, indicating that CRF is involved in the BE response. Its effect is likely exerted in extra-hypothalamic sites rather than in hypothalamic sites controlling the hypothalamic–pituitary–adrenal axis. In addition, orexin-1 receptor antagonists selectivity inhibit BE; studies are under way to evaluate whether their effects are related to influences on stress or on reward mechanisms. This preclinical model appears to be highly reliable and reproducible; it may represent a valid model to identify novel pharmacological treatments of BE disorder and bulimia nervosa.